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Spring 2021 Schedule

January 20
Jiacheng Miao: “A quantile integral linear model to identify genetic loci affecting phenotypic variability”

January 27
Eva Vasiljevic and Yuetiva Robles: “Alzheimer’s disease PGS validity and reliability across studies”

February 17
Xiaoyuan Zhong: “Using survey weight to account for participation bias in the UK Biobank”

February 24
Madison-Amsterdam Journal Club (hosted by Vrije Universiteit Amsterdam) – Yuchang Wu, discussed F. Privé, H. Aschard, L. Folkersen, et al., “High-resolution portability of 240 polygenic scores when derived and applied in the same cohort”
medRxiv

March 3
Kristen Malecki: “Population Health Sciences and Opportunities for Aging Socio-genomics Research” (Video)

March 10
Jason Fletcher: “Understanding Sibling Correlations in Education: Genetics and Family Background”

March 17
Burcu Darst (USC, Postdoctoral Scholar), guest presenter: “Development and application of polygenic risk scores across diverse populations” (Video)
Nature Genetics

March 31
Alicia Martin (Broad Institute and Massachusetts General Hospital), guest presenter: “Polygenic risk scores for the world: current applications, limitations, and promise” (Video)

April 14
Jasmin Wertz (Duke), guest presenter: “Parental investment across a child’s life: Genetic analysis in a multi-cohort study”

Fall 2020 Schedule

November 19
Andrew Grotzinger (UT Austin), guest presenter: “Using Genomic SEM to Understand Psychiatric Comorbidity” (Video)

November 12
Philipp Koellinger: “Genetic data in the German Socio-Economic Panel”

November 5
Jonathan Beauchamp (George Mason University), guest presenter: “Nature and Nurture: Evidence from Molecular Genetics Data in Adoptees” (Video)

October 22
Madison-Amsterdam Journal Club – Andries Marees (Vrije Universiteit Amsterdam)

October 15
Ben Domingue (Stanford University), guest presenter: “Heteroscedastic regression modeling elucidates gene-by-environment interaction” (Video)

October 8
Rosa Cheesman (King’s College London), guest presenter: “How important are parents in the development of child anxiety and depression? A genomic analysis of parent-offspring trios in the Norwegian Mother Father and Child Cohort Study (MoBa)” (Video)

September 25
Madison-Amsterdam Journal Club – Sjoerd van Alten (Vrije Universiteit Amsterdam): “Mendelian imputation of parental genotypes for genome-wide estimation of direct and indirect genetic effects”

September 10
Yuchang Wu: “Estimating genetic nurture using summary statistics of multi-generational genome-wide association study”

September 3
Overview/announcements and introductions, followed by breakout rooms

Summer 2020 Schedule

August 25
Sam Trejo: “The Phenotype Differences Model: Identifying Genetic Effects with Incomplete Sibling Data”

August 18
Frank He: “Examining polygenic protective effect in ADHD” (with James Li and Qiongshi Lu)

August 11
Joseph Clark: “Religious Context and Genetic Influences on Adolescent Drinking”

August 4
Xiaoyuan Zhong: “Understanding participation bias in UK Biobank”

July 14
Rebecca Johnson (Dartmouth), guest presenter: “v-PGS: A New Tool for G x E” (Video)
bioRxiv

July 7
Boyan Zheng: “Genetic-by-Peer-Environment Interaction Effects on Adolescent Substance Use”

June 30
Philipp Koellinger: Genetic and neuroscientific insights on socio-economic status based on results from two ongoing projects; summary of BIG BEAR consortium projects

June 9
Jiacheng Miao: “Quantile regression approach to detect vQTL”

Spring 2020 Schedule

April 29
Lauren Schmitz: “Social Determinants of DNA Methylation Signatures in MESA”

April 22
Yuchang Wu: “Dissecting direct and indirect genetic effects using GWAS summary statistics”

April 1
Jason Fletcher: Family Analysis with PGS

March 25
Hyunseung Kang and Sheng Wang: Sleep and AD

March 11
Hyunseung Kang and Sheng Wang / Jason Fletcher and Boyan Zheng: IV

March 4
Discussion on GWAS on age at first marriage

February 26
Julie Goodwin and Lauren Schmitz / Qiongshi Lu and Jiacheng Miao: V-PGS Methods and Results

February 19
Discussion on local genetic correlation; and “How to pick a research topic”

February 12
Lauren Schmitz: Functional PGS
Jason Fletcher and Boyan Zheng: HRS replication

January 29
Yuchang Wu: Updates on (1) Genetics meets population science: understanding the importance of response rates in genetic; (2) Discovery and prediction in the UK Biobank; and (3) Dissecting direct and indirect genetic effects using GWAS summary statistics.

January 22
Introductions and project updates
Lauren Gaydosh (Vanderbilt), guest attendee

Fall 2019 Schedule

December 9
Caiping Wei (UNC, Chapel Hill), guest presenter: “Genes, Gender Inequality, and Educational Attainment,” American Sociological Review paper

December 2
Qiongshi Lu: Updates on (1) Gamete simulation and its applications; (2) Dissecting direct and indirect genetic effects using GWAS summary statistics; and (3) Tissue-specific PGS.

November 25
Scott Hebbring (Marshfield Clinic), guest attendee
Discussion of collaboration opportunities

November 18
Hyunseung Kang and Sheng Wang: “Causal Analysis of Educational Attainment and Alzheimer’s Disease: Mendelian Randomization and Instrumental Variable Approach”

November 11
Lauren Gaydosh (Vanderbilt), guest attendee
Philipp Koellinger (Vrije Universiteit Amsterdam), guest presenter: Showcase and GIV/MR short course
Student Presentations:
Eva Vasiljevic: “Effect of early-life nutrition on dementia: a natural experiment leveraging the US pellagra epidemic”
Boyan Zheng: “Differential Genetic Susceptibility to Peer’s Depression: Methods and Findings”
Shiro Furuya: “Detecting Genetic Heterogeneities in Response to Trauma: The Case of 9/11”
Joseph Clark: “Religious Contexts and Genetic Influences on Drinking Behaviors”
Julie Goodwin and Lauren Schmitz: “The Impact of Job Loss and Genotype on Health and Health Behaviors”
Jiacheng Miao: “Testing gene-environment interaction without measuring the environment”
Yuchang Wu: “Birth order and smoking/pregnancy”; “Fine-tuning PGS” (Zijie Zhao‘s project)
Yuexuan Xu: “Social effects of baldness PGS”

November 4
Kevin Thom (UW–Milwaukee), guest attendee

October 28
Student Presentations:
Julia Carlson, Joseph Clark, and Yuexuan Xu: “Clinical Use of Polygenic Risk Scores (PRS)”
Shiro Furuya and Boyan Zheng: “Deconstructing the sources of genotype-phenotype associations”

October 21
Student Presentations:
Sheng Wang and Zijie Zhao: “The Nature of Nurture”
Julie Goodwin and Eva Vasiljevic: “Variable Prediction Accuracy of PGS Within Ancestry Group”

October 7
Project updates; and IGSS summary and reflection

September 30
L.H. Lumey (Columbia University), guest attendee

September 16
Amy Cochran (UW–Madison, Population Health), guest presenter: “Gene-Set Enrichment with Mathematical Biology”

September 9
Introductions and project updates
Lauren Schmitz: Updates on Specific Aims for R21
Yuchan Wu: Updates on (1) Birth order GWAS+PGS project; (2) Sex-stratified GWAS on smoking behavior in the UKBB; and (3) GWAS of AD family history in the UK Biobank.
Discussion on building an infrastructure to share AddHealth/WLS/HRS genetic and phenotypic data between groups.